By Jeffrey Wang,Wei-Chiang Shen,Jennica L. Zaro
This authoritative quantity presents a holistic photo of antibody-drug conjugates (ADCs). Fourteen finished chapters are divided into six sections together with an advent to ADCs, the ADC build, improvement matters, panorama, IP and pharmacoeconomics, case stories, and the way forward for the sector. The publication examines every thing from the choice of the antibody, the drug, and the linker to a dialogue of developmental concerns resembling formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory demanding situations. It additionally explores pharmacoecomonics and highbrow houses, together with lately issued patents and the fee research of drug remedy. Case reviews are offered for the 3 ADCs that experience got FDA approval: gemtuzumab ozogamicin (Mylotarg®), Brentuximab vedotin (Adcetris®), and ado-trastuzumab emtansine (Kadcyla®), in addition to an ADC in late-stage medical trials, glembatumumab vedotin (CDX-011). eventually, the quantity provides a point of view through the editors at the destiny instructions of ADC improvement and scientific purposes. Antibody-Drug Conjugates is a realistic and systematic source for scientists, professors, and scholars attracted to increasing their wisdom of state-of-the-art examine during this intriguing field.
Read or Download Antibody-Drug Conjugates: The 21st Century Magic Bullets for Cancer (AAPS Advances in the Pharmaceutical Sciences Series) PDF
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This authoritative quantity presents a holistic photograph of antibody-drug conjugates (ADCs). Fourteen finished chapters are divided into six sections together with an advent to ADCs, the ADC build, improvement concerns, panorama, IP and pharmacoeconomics, case reviews, and the way forward for the sphere.
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Additional info for Antibody-Drug Conjugates: The 21st Century Magic Bullets for Cancer (AAPS Advances in the Pharmaceutical Sciences Series)
Antibody-Drug Conjugates: The 21st Century Magic Bullets for Cancer (AAPS Advances in the Pharmaceutical Sciences Series) by Jeffrey Wang,Wei-Chiang Shen,Jennica L. Zaro